Pfizer and BioNTech speed up timeline for offering Covid-19 vaccine to placebo volunteers

first_img @matthewherper By Matthew Herper Jan. 1, 2021 Reprints 3 biotech trends to watch in 2021 [email protected] Privacy Policy Michael Tovar, a volunteer who had been publicly campaigning for Pfizer to offer the vaccine more quickly to participants in the 44,000-person clinical trial, thanked the company and its chief executive on Twitter. Newsletters Sign up for Daily Recap A roundup of STAT’s top stories of the day. Senior Writer, Medicine, Editorial Director of Events Matthew covers medical innovation — both its promise and its perils. A pharmacist prepares the Pfizer/BioNTech vaccine for administration. Brendan Smialowski/Getty Images Leave this field empty if you’re human: Goodman laid out a complicated scheme, known as a double-blind crossover study, in which all volunteers who wanted to be sure they received the vaccine would be offered two more shots. Those who had received the vaccine would be offered placebo, and those who had received placebo would be offered the vaccine.William Gruber, one of Pfizer’s top vaccine executives, argued that this plan was unworkable. Essentially, it would require running a large part of the study a second time.Instead, Pfizer set out a plan in which volunteers who wanted the vaccine could receive it when they would be eligible to receive the vaccine in their local area. Health care personnel or residents in long-term care facilities, who were already eligible to be vaccinated, would get the vaccine immediately.“If you are not health care personnel or a resident in a long-term care facility (or in any other future added group), we will discuss an option to transition from the placebo group to the vaccine group at your fourth study visit, approximately six months after you originally received your second injection,” a letter sent to participants in late December said. “We respectfully ask that you wait until Study Visit #4 to discuss the Vaccine Transition Option.”This complicated process was moving forward quickly, because many of the participants in the study were health care providers. According to the letter obtained by STAT, 2,000 volunteers who received placebo have already gotten their first dose of the Pfizer vaccine. But it was clear that others would have to wait.But then, on Dec. 17, the FDA held another advisory meeting, this time for Moderna’s vaccine, which had been developed more closely with Operation Warp Speed. Again, Goodman made his presentation. A researcher representing Moderna made a case, as Pfizer had, that his idea was impractical, and laid out a plan for giving placebo-receiving volunteers the vaccine much faster than Pfizer would. They would not have to wait until they were eligible to get vaccinated outside the trial.The FDA’s advisers spent considerable time comparing Goodman’s plan to Moderna’s, eventually agreeing that Goodman’s was unworkable. But they spent little time comparing Pfizer’s plan, which delayed vaccine longer, to Moderna’s.That left Pfizer in a bind, as more and more volunteers publicly protested that they should be offered the vaccine if they received placebo.Alan S. Goldsmith, a retired physician in Florida who volunteered for the Pfizer trial, told STAT that he and his wife, who also volunteered for the study, did not even expect they’d get the vaccine if they were in the placebo group. They just wanted to know if they had already received the vaccine. “What it would allow us to do is know our vaccination status which might allow a little more freedom to do things like visit our grandchildren,” he wrote.On Dec. 23, Moncef Slaoui, the head of Operation Warp Speed, told reporters that he thought volunteers who had received placebo should receive the vaccine at once, contradicting the FDA. He also called the Pfizer plan intellectually elegant but impractical, saying that with different requirements for vaccination in all 50 states, it would be difficult to administer.Pfizer was apparently already working to make its plan for crossover more like Moderna’s. New language posted on its website for trial participants on New Year’s Eve stated that vaccine doses had been secured, and that it and BioNTech aimed for all participants who received the placebo to have the opportunity to get their first dose of the vaccine by March 1, if they choose to.A letter from Nicholas Kitchin, a senior director in Pfizer’s vaccine clinical research and development group, struck a cheerful tone for a clinical document.“We recognize that our clinical trial participants are selfless volunteers who have made the important choice to make a difference and fight this pandemic,” Kitchin wrote.“While the study continues to be blinded to answer important public health questions such as persistence of protection, longer term safety and protection from asymptomatic infections, we are committed to ensuring that our trial participants are recognized for their contributions and that placebo recipients who wish to can receive BNT162b2 within the study.” HealthPfizer and BioNTech speed up timeline for offering Covid-19 vaccine to placebo volunteers Tags Coronavirusvaccine Pfizer and BioNTech revealed the decision on a website for clinical trial participants and in a letter, obtained by STAT, that was sent to researchers conducting the clinical trial.The letter to researchers indicated they are also asking participants to take additional Covid tests, to be conducted by clinical trial volunteers at home, to help understand whether the vaccine, which reduces symptomatic infections by 95%, also prevents asymptomatic infection. The answer to that question is important; currently, there is no way to know whether people who received the vaccine can still transmit it to others.In medicine, the most reliable answers about treatments and preventatives come from double-blind placebo-controlled trials. This means that patients are randomly assigned to receive either the treatment, in this case a vaccine, or placebo. Neither they nor their doctor knows what they have received. In many trials, such as those for cancer, it’s simply assumed that patients who received placebo will get the treatment once the study is completed. This step is known as crossover.But the matter of how placebo crossover should be handled during a pandemic was left open by both the FDA and the U.S. government’s Operation Warp Speed effort, which sped vaccine development, when the studies began in July. Consent forms given to volunteers, obtained by STAT, made no mention of when or if those who received placebo would get the two-dose vaccine.At a Dec. 10 meeting of an advisory committee regarding the emergency use authorization of the Pfizer/BioNTech vaccine, the FDA discussed how the placebo crossover should be handled. At that session, Steven Goodman, associate dean of clinical and translational research at the Stanford University School of Medicine, argued that there was no ethical reason that volunteers in the placebo group deserved to receive vaccine before the general public. Matthew Herper Related: “Thank you for listening and for changing your study protocol to allow for speedy vaccination of your placebo arm,” Tovar wrote. “You have made this New Year so much brighter for the 22,000 placebo volunteers that stepped up for this vaccine.”advertisement Pfizer and its partner BioNTech plan to offer their Covid-19 vaccine to any clinical trial volunteer who received placebo by March 1, several months earlier than initially planned.The decision represents the conclusion of a complex and public kabuki dance between the Food and Drug Administration, Pfizer, and vaccine volunteers, as well as with Moderna, which developed its own Covid-19 vaccine. The FDA and its advisers pushed hard for volunteers to remain on placebo as long as possible to gather more safety and efficacy data about the vaccines, while the companies argued volunteers should receive the vaccines sooner for both ethical and practical reasons.Among some trial participants, the issue had become fraught, with many protesting further delays in heated messages on social media and in letters to media organizations, including STAT.advertisement Please enter a valid email address. About the Author Reprintslast_img read more

Crosby loves Seminole; soon the world will too

first_imgSeminole Golf Club holds a special place in Nathaniel Crosby’s heart. For Crosby, it was love at first sight when, at age 15, he played his earliest rounds on the Donald Ross-designed South Florida gem for four days in 1976, with his legendary father Bing Crosby, his brother Harry, his father’s very best friend George Coleman (later Seminole’s president) and another legacy member in Mickey Van Gerbig, whose brother Barry also went on to serve as club president. A year later, after his father’s tragic passing in Spain, Crosby was invited by Coleman for four more days of golf at Seminole, this time with larger-than-life pro Ben Hogan. Crosby remembers the New Year’s Eve party on that trip where Hogan, cigarette holder and all, introduced himself to a Palm Beach socialite woman. “Hi, I’m Ben Hogan,” he said. To which the woman responded: “Yes, you are!” Crosby remained a frequent guest of Coleman’s. He received a golf scholarship to the University of Miami and spent many afternoons at nearby Jupiter Hills beating balls under the tutelage of instructor Tony Penna, but for a young Crosby, the opportunity to live close to Seminole was arguably the greatest benefit to calling South Florida home. Every season, Seminole allowed guests to play up to 25 times. “I was always pretty close to that,” Crosby said. Now 58, Crosby, the 1981 U.S. Amateur champion, has been a member at Seminole for years. He’s won a club championship there. He’ll look to captain a second straight winning U.S. Walker Cup team there next May. And he, along with the other titans of industry and true world-beaters that make up Seminole’s membership, will proudly watch as the club enjoys its big public unveiling Sunday. Getty Images The TaylorMade Driving Relief, a team skins event matching up Rory McIlroy and Dustin Johnson against Rickie Fowler and Matthew Wolff, will mark the first televised event at Seminole. But even with four of golf’s biggest stars on display, Crosby believes Seminole will shine brightest. “I think the golf course is going to hold up extremely well,” said Crosby, who actually is McIlroy’s next-door neighbor in Jupiter. “It’s such a special place. … People are going to fall in love with it when they see it.” Added mid-amateur Stewart Hagestad, who has played Seminole several times and lists it as his favorite course in the world: “It’s one of those places where the more you play it, the more respect you get for it,” he said. Crosby hosted Hagestad and 15 more of the top American amateurs, including Wolff, two Decembers ago for the Walker Cup practice session. The first handful of rounds were played on other courses in the area, including Medalist and Bear’s Club, and the youngsters blitzed those layouts. Duke’s Alex Smalley and Vanderbilt’s John Augenstein shot 61 in alternate shot together on their first trip around Bear’s Club. But when they arrived at Seminole? “Let’s just say they didn’t beat up Seminole,” Crosby said. News & Opinion Driving Relief a small step toward live sports BY Rex Hoggard  — May 16, 2020 at 8:00 PM What the Driving Relief match lacks in official standing or meaningful competition can easily be overlooked thanks to one simple theme: Golf is back. Crosby says Seminole, which is set in a basin along the Atlantic Ocean amongst two massive sandy ridges, is more difficult now than back when he played it as a teenager. There’s a lot less vegetation, with fewer trees amplifying the wind, which can give even the best players headaches since no three consecutive holes at Seminole play with the same wind direction. “If it’s blowing 10 mph at Bear’s Club, it’s blowing 20 at Seminole, and it’s a huge difference,” Crosby said. The greens are much firmer these days, too. Whereas players were once able to get to tucked pins with some ease many years ago, it’s now even more imperative that players play to the proper angles – even if they’ll have a wedge in their hands for their second shots. Some hole locations require less than a 10-square-foot landing area and an approach shaped into the wind. “Unless you hit the ball down an elevator shaft, it’s very hard to go at one of those pins,” Crosby said. Add in several lengthened holes – a handful of new tee boxes were put in for next spring’s Walker Cup – and fast greens (expected to be pushing 13 on the Stimpmeter) with many hidden intricacies, and Crosby predicts a hard-fought battle. “There will be some birdies,” said Crosby, who set the over/under at an average of three-and-a-half birdies per player. “But there will also be some three-putts, I promise you that.” Crosby’s deep knowledge of the remarkable layout is on full display as he goes through his favorite holes. For those watching along at home Sunday, Crosby recommends paying extra attention to these five: No. 4 Crosby expects this uphill par 4, the course’s No. 1 handicap hole, to play from a new back tee, about 510 yards long, and more than likely into a prevailing wind. “It’s a classic, straight-away, knock-yourself-out golf hole,” he said. A birdie here by anyone would be shocking. Getty Images No. 6 Often touted as Hogan’s favorite hole, Crosby says the real challenge on this par 4 is the approach shot. Players will likely have a wedge into this green, which runs diagonally from front left to back right, but it’s not a guaranteed birdie hole. The center of the green is the narrowest portion, bottlenecked by two bunkers. With a back-right pin the likely location, Crosby says, this forces one of two shots. “If you hit it left to play safe, it can jump into the back-left bunker, which is not visible from fairway, so you have to under-club and hit it safely to the left or you have to shoot for the pin and carry it all the way to the back.” Getty Images No. 12 Another short par 4 for these long-hitting pros, and another hole where wedge doesn’t necessarily equate to a birdie. “It’s such a daunting hole,” Crosby said, “because even though it’s a short hole for these guys, it’s a coffee-table green with a small target. If the pin is in the back, you have to curve [your shot] against the wind. If you let the wind take it, you’ve probably got about a landing area of 12 square feet.” No. 13 “It looks like you can throw a football from the tee to the green,” Crosby said. But this par 3, which plays around 165 yards into the wind, isn’t that easy. If the pin is tucked in the right corner, “it will be fun to watch.” Getty Images No. 18 An ideal finisher, Crosby states, and a hole made even more exciting by a $500,000 skin. Players can try to cut off some distance on this dogleg-left hole, and the elevated green is protected by a false front and deep right bunker. “If the pin is in the front and a player spins a wedge too much, that ball could roll almost back to their feet,” Crosby said. If the players are tied after the 18th hole, they will head back to the par-3 17th hole, where they will play it up, from about 125 yards. If they are tied again, or don’t finish 18 holes before 5:45 p.m. ET, the tie will be settled on the penultimate hole using a closest-to-the-pin format. Either way, play will be done by 6 p.m. That’s the rule at Seminole, and it has been for a long time as the club implemented it in order to prevent members from lingering and keeping the staff working long into the evening. Crosby has had some close calls, including one time when his brother, Harry, was having “the round of his life,” 2 under through 16 holes, when they were forced to call it quits and retreat to the clubhouse. “I don’t know if he is over that,” Crosby said with a laugh. As for Crosby, he’ll likely never get over his infatuation for Seminole. And for those tuning in Sunday, get ready to fall in love.last_img read more

Women Activists Clean Up and Revitalize Libyan City

first_imgAyadina uses such community improvement projects — and the media attention they attract — as a platform to promote civic engagement and political involvement. During the cleanup campaigns, for example, flyers were handed out with basic information on constitutional principles and processes prior to the election of a Constitution Drafting Assembly that will write Libya’s first new constitution in 40 years.“We have received a lot of positive feedback from community residents,” said Haneia Muftah Gamatti, chairperson of Ayadina. “I see the activity at the park and know that we have done something good that will contribute to improving Benghazi.”Photo: Libya Transition Initiative AddThis Sharing ButtonsShare to FacebookFacebookFacebookShare to TwitterTwitterTwitterShare to EmailEmailEmailShare to RedditRedditRedditShare to MoreAddThisMore AddThis Sharing ButtonsShare to FacebookFacebookFacebookShare to TwitterTwitterTwitterShare to EmailEmailEmailShare to RedditRedditRedditShare to MoreAddThisMoreIn downtown Benghazi, a dark and deserted park is now bustling with life. Fathers and mothers bring their children to play on the new playground and enjoy the safe space. With four schools in the surrounding area, teachers now bring their students to the park for physical education classes.The project was implemented by Ayadina, a women-led civil society organization that seeks to support and engage youth in Benghazi. The park and other projects to spark positive change are supported by the USAID.Ayadina also spearheaded campaigns to clean up Benghazi’s littered beachfront, raise awareness of the importance of environmental protection, and distribute information on the development of Libya’s new constitution.Last September, the group led a series of beach cleanups at four locations with help from dozens of Boy Scouts. Local businesspeople donated 40 metal garbage bins that were placed along the shorefront. The campaign spread to the sea as four scuba divers volunteered to collect waste underwater.last_img read more

SpongeBob SquarePants, Harry Potter and the Cursed Child & My Fair Lady Top 2018 Outer Critics Circle Nominations

first_imgThe nominations for the 2018 Outer Critics Circle Awards are here! The new musical SpongeBob SquarePants heads the list with 11 nominations, followed just behind by the two-part play Harry Potter and the Cursed Child with 10 noms and the revival of My Fair Lady which was honored with nine nominations. Winners of the 2018 Outer Critics Circle Awards will be announced on May 7.Please note: The off-Broadway production of The Band’s Visit was nominated for and received multiple awards from the Outer Critics Circle last season and therefore was not considered again for its Broadway run.Find the full list of nominees below.OUTSTANDING NEW BROADWAY PLAYThe ChildrenFarinelli and the KingHarry Potter and the Cursed ChildJunkOUTSTANDING NEW BROADWAY MUSICALEscape to MargaritavilleFrozenMean GirlsPrince of BroadwaySpongeBob SquarePantsOUTSTANDING NEW OFF-BROADWAY PLAYAdmissionsCost of LivingHangmenThe Low RoadMlima’s TaleOUTSTANDING NEW OFF-BROADWAY MUSICALCruel IntentionsDesperate MeasuresJerry Springer — The OperaMiss You Like HellWoody SezOUTSTANDING REVIVAL OF A PLAY (Broadway or Off-Broadway)Angels in AmericaJesus Hopped the ‘A’ TrainLobby HeroThree Tall WomenTravestiesOUTSTANDING REVIVAL OF A MUSICAL (Broadway or Off-Broadway)CarouselMy Fair LadyOnce On This IslandPacific OverturesOUTSTANDING BOOK OF A MUSICAL (Broadway or Off-Broadway)Tina Fey, Mean GirlsQuiara Alegría Hudes, Miss You Like HellKyle Jarrow, SpongeBob SquarePantsPeter Kellogg, Desperate MeasuresOUTSTANDING NEW SCORE (Broadway or Off-Broadway)SpongeBob SquarePants (Yolanda Adams, Steven Tyler and Joe Perry of Aerosmith, Sara Bareilles, Jonathan Coulton, Alexander Ebert of Edward Sharpe & the Magnetic Zeros, the Flaming Lips, Lady Antebellum, Cyndi Lauper, John Legend, Panic! at the Disco, Plain White T’s, Tom Kenny and Andy Paley, They Might Be Giants, T.I., David Bowie and Tom Kitt)Desperate Measures (David Friedman and Peter Kellogg)Harry Potter and the Cursed Child (Imogen Heap)Miss You Like Hell (Erin McKeown and Quiara Alegría Hudes)Frozen (Kristen Anderson-Lopez and Robert Lopez)OUTSTANDING ACTOR IN A PLAYSean Carvajal, Jesus Hopped the ‘A’ TrainAndrew Garfield, Angels in AmericaTom Hollander, TravestiesGregg Mozgala, Cost of LivingMichael Urie, The Government InspectorOUTSTANDING ACTRESS IN A PLAYMaameYaa Boafo, School Girls; Or, the African Mean Girls PlayJessica Hecht, AdmissionsGlenda Jackson, Three Tall WomenLauren Ridloff, Children of a Lesser GodKaty Sullivan, Cost of LivingOUTSTANDING ACTOR IN A MUSICALHarry Hadden-Paton, My Fair LadyJoshua Henry, CarouselDavid M. Lutken, Woody SezConor Ryan, Desperate MeasuresEthan Slater, SpongeBob SquarePantsOUTSTANDING ACTRESS IN A MUSICALLauren Ambrose, My Fair LadyErika Henningsen, Mean GirlsHailey Kilgore, Once On This IslandTaylor Louderman, Mean GirlsPatti Murin, FrozenOUTSTANDING FEATURED ACTOR IN A PLAYAnthony Boyle, Harry Potter and the Cursed ChildJohnny Flynn, HangmenNathan Lane, Angels in AmericaDavid Morse, The Iceman ComethPaul Sparks, At Home at the ZooOUTSTANDING FEATURED ACTRESS IN A PLAYJamie Brewer, Amy and the OrphansDenise Gough, Angels in AmericaHarriet Harris, The Low RoadLaurie Metcalf, Three Tall WomenMary Testa, The Government InspectorOUTSTANDING FEATURED ACTOR IN A MUSICALNorbert Leo Butz, My Fair LadyAlexander Gemignani, CarouselGavin Lee, SpongeBob SquarePantsNick Wyman, Desperate MeasuresTony Yazbeck, Prince of BroadwayOUTSTANDING FEATURED ACTRESS IN A MUSICALKerry Butler, Mean GirlsLindsay Mendez, CarouselLauren Molina, Desperate MeasuresAshley Park, Mean GirlsEmily Skinner, Prince of BroadwayOUTSTANDING SOLO PERFORMANCEBilly Crudup, Harry ClarkeEve Ensler, In the Body of the WorldAlison Fraser, SqueamishJohn Lithgow, Stories by HeartSharon Washington, Feeding the DragonOUTSTANDING DIRECTOR OF A PLAYJo Bonney, Cost of LivingMarianne Elliott, Angels in AmericaPatrick Marber, TravestiesJoe Mantello, Three Tall WomenJohn Tiffany, Harry Potter and the Cursed ChildOUTSTANDING DIRECTOR OF A MUSICALMichael Arden, Once On This IslandBill Castellino, Desperate MeasuresTina Landau, SpongeBob SquarePantsCasey Nicholaw, Mean GirlsBartlett Sher, My Fair LadyOUTSTANDING CHOREOGRAPHERCamille A. Brown, Once On This IslandChristopher Gattelli, My Fair LadyChristopher Gattelli, SpongeBob SquarePantsSteven Hoggett, Harry Potter and the Cursed ChildJustin Peck, CarouselOUTSTANDING SET DESIGN (Play or Musical)Miriam Buether, Three Tall WomenMyung Hee Cho, In the Body of the WorldChristine Jones, Harry Potter and the Cursed ChildMichael Yeargan, My Fair LadyDavid Zinn, SpongeBob SquarePantsOUTSTANDING COSTUME DESIGN (Play or Musical)Katrina Lindsay, Harry Potter and the Cursed ChildClint Ramos, Once On This IslandPaloma Young, Time and the ConwaysDavid Zinn, SpongeBob SquarePantsCatherine Zuber, My Fair LadyOUTSTANDING LIGHTING DESIGN (Play or Musical)Kevin Adams, SpongeBob SquarePantsNeil Austin, Harry Potter and the Cursed ChildPaule Constable, Angels in AmericaPaul Russell, Farinelli and the KingLap Chi Chu, Mlima’s TaleOUTSTANDING PROJECTION DESIGN (Play or Musical)Tim Reid, 1984Finn Ross, FrozenFinn Ross, In the Body of the WorldFinn Ross and Adam Young, Mean GirlsFinn Ross and Ash Woodward, Harry Potter and the Cursed ChildOUTSTANDING SOUND DESIGN (Play or Musical)Gareth Fry, Harry Potter and the Cursed ChildKate Marvin, [Porto]Fitz Patton, Napoli, BrooklynMarc Salzberg, My Fair LadyDarron L. West, Mlima’s TaleOUTSTANDING ORCHESTRATIONSJason Robert Brown, Prince of BroadwayTom Kitt, SpongeBob SquarePantsAnnMarie Milazzo and Michael Starobin, Once On This IslandJonathan Tunick, CarouselClaire Van Kampen, Farinelli and the KingJOHN GASSNER AWARD (Presented for an American play, preferably by a new playwright)Kate Benson, [Porto]Jocelyn Bioh, School Girls; Or, the African Mean Girls PlayLindsey Ferrentino, Amy and the OrphansMeghan Kennedy, Napoli, BrooklynDominique Morisseau, PipelineNominations tally for three or more:SpongeBob SquarePants—11Harry Potter and the Cursed Child—10My Fair Lady—9Mean Girls—8Desperate Measures—7Angels in America—6Carousel—6Once On This Island—6Three Tall Women—5Cost of Living—4Frozen—4Prince of Broadway—4Farinelli and the King—3In the Body of the World—3Mlima’s Tale—3Miss You Like Hell—3Travesties—3 View Commentslast_img read more

Former Baylor Coach Art Briles Shows Up at Browns Practice as Guest Coach

first_img Related TopicsArt BrilesBrownsHue JacksonNFL The Browns had a new face on sidelines during practice on Wednesday, as coach Hue Jackson brought in former Baylor football coach Art Briles to serve as a guest coach.In case you forgot, Briles was fired in the wake of a sexual assault scandal at the school.The coach does have a connection with the Browns, as he was the coach for QB Robert Griffin III.“Hey, I’ll learn from anybody if they can help us,” Jackson said on Wednesday after practice. “Obviously, he’s a very accomplished college coach and has done outstanding. I wish him well. He’s done just outstanding at Baylor, but at the same time, I think he was here to see his guys and get an opportunity to see us, our organization and what we do, but more so see his football players.”The Baylor coach was canned back in late May after a sexual assault scandal at Baylor broke out which involved a number of players. Jackson didn’t specify how long Briles would be with the Browns as a guest coach.“Everybody deserves an opportunity to do what they do,” Jackson said. Matt Loedecenter_img Matt Loede has been a part of the Cleveland Sports Media for over 21 years, with experience covering Major League Baseball, National Basketball Association, the National Football League and even high school and college events. He has been a part of the Cleveland Indians coverage since the opening of Jacobs/Progressive Field in 1994, and spent two and a half years covering the team for 92.3 The Fan, and covers them daily for Associated Press Radio. You can follow Matt on Twitter HERE.last_img read more

Girls Dominate Last Night In Tigers Swim-Team Action

first_imgBy Paul LeckerSports ReporterMERRILL – The Marshfield girls swim team won its Wisconsin Valley Conference dual meet opener Thursday, whipping Merrill 118-48 at Merrill High School.Marshfield won eight of the 11 events.Sophie Koehn, Elizabeth Holbrook, Megan Donahue, and Sarah Claessens teamed to win the 200 medley relay (2:09.07) and the 400 freestyle relay (4:23.78), and all four also won individual events for the Tigers.Holbrook won the 200 individual medley (2:33.93) and the 100 breaststroke (1:20.33), Donahue won the 100 butterfly (1:10.96), Claessens took first in the 500 freestyle (6:16.54) and Koehn was first in the 100 backstroke (1:09.10).April Read grabbed the other first place for the Tigers, winning the 200 freestyle in 2:30.60.Valerie Kushnir (200 free), Elizabeth Lecker (50 free), Molina Barker (100 free), Michelle Fernandez (100 back), and Claire Greenlee (100 breaststroke) won events for the Marshfield JV.Marshfield is off for a week until taking on D.C. Everest in a Wisconsin Valley Conference dual on Sept. 18 at Marshfield High School.VarsityWinners and Marshfield finishersMarshfield 118, Merrill 48200 medley relay: 1. Marshfield (Sophie Koehn, Elizabeth Holbrook, Megan Donahue, Sarah Claessens) 2:09.07; 3. Marshfield (Karen Scheuer, Grace Hilbelink, Valerie Kushnir, Charlotte Urban) 2:22.22; 4. Marshfield (Molina Barker, Michelle Fernandez, April Read, Elise Ashby) 2:22.93.200 freestyle: 1. Read (MAR) 2:30.60; 4. Barker (MAR) 2:41.16; 5. Morgan Nordbeck (MAR) 2:44.28.200 IM: 1. Holbrook (MAR) 2:33.93; 2. Scheuer (MAR) 2:46.62; 3. Madi Hall (MAR) 3:02.24.50 freestyle: 1. Kendyl Pettit (MER) 27.51; 2. Claessens (MAR) 27.97; 3. Erika Roeglin (MAR0 31.16; 4. Ashby (MAR) 31.90.100 butterfly: 1. Donahue (MAR) 1:10.96; 2. Ashby (MAR) 1:26.40; 3. Urban (MAR) 1:37.39.100 freestyle: 1. Pettit (MER) 1:00.55; 2. Koehn (MAR) 1:01.81; 3. Read (MAR) 1:10.99; 4. Michelle Fernandez (MAR) 1:11.23.500 freestyle: 1. Claessens (MAR) 6:16.54; 2. Kushnir (MAR) 6:44.60; 5. Hall (MAR) 7:11.91.200 freestyle relay: 1. Merrill (Caitlyn Kolehouse, Hanna Cohrs, Julia Oelke, Pettit) 2:01.32; 2. Marshfield (Fernandez, Roeglin, Ashby, Urban) 2:03.01; 3. Marshfield (Claire Greenlee, Read, Scheuer, Hilbelink) 2:11.64.100 backstroke: 1. Koehn (MAR) 1:09.10; 2. Donahue (MAR) 1:11.16; 3. Scheuer (MAR) 1:18.47.100 breaststroke: 1. Holbrook (MAR) 1:20.33; 2. Urban (MAR) 1:30.89; 3. Hilbelink (MAR) 1:33.77.400 freestyle relay: 1. Marshfield (Claessens, Holbrook, Donahue, Koehn) 4:23.78; 2. Marshfield (Lecker, Nordbeck, Barker, Kushnir) 4:55.81.JVMarshfield 48, Merrill 6200 freestyle: 1. Kushnir (MAR) 2:37.39; 2. Hilbelink (MAR) 2:47.24; 3. Taylor Ferch (MAR) 2:53.29.50 freestyle: 1. Lecker (MAR) 33.88; 2. Ferch (MAR) 36.10; 4. Nina Meadows (MAR) 43.01.100 freestyle: 1. Barker (MAR) 1:13.38; 2. Nordbeck (MAR) 1:16.53; 3. Tess Frey (MAR) 1:18.29.100 backstroke: 1. Fernandez (MAR) 1:26.64; 2. Lecker (MAR) 1:43.62.100 breaststroke: 1. Greenlee (MAR) 1:44.90; 2. Roeglin (MAR) 1:49.18; 3. Frey (MAR) 1:59.31.(Hub City Times Sports Reporter Paul Lecker is also the publisher of  MarshfieldAreaSports.com).last_img read more

The State Of Advanced Website Builders

first_img HomeWeb DesignThe State Of Advanced Website Builders Advanced website builders — the tools provided by Squarespace, Wix, Weebly, The Grid and more — produce websites that look and feel like they were designed and coded by humans. They’re also software as a service, which is a different business model than traditional, custom-developed websites.So, should companies use them? At some point, will they replace custom development? In short, yes.The post The State Of Advanced Website Builders appeared first on Smashing Magazine.From our sponsors: The State Of Advanced Website Builders The State Of Advanced Website BuildersYou are here: Related postsInclusive Components: Book Reviews And Accessibility Resources13th December 2019Should Your Portfolio Site Be A PWA?12th December 2019Building A CSS Layout: Live Stream With Rachel Andrew10th December 2019Struggling To Get A Handle On Traffic Surges10th December 2019How To Design Profitable Sales Funnels On Mobile6th December 2019How To Build A Real-Time Multiplayer Virtual Reality Game (Part 2)5th December 2019 Posted on 5th June 2017Web Design FacebookshareTwittertweetGoogle+sharelast_img read more